Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems
نویسندگان
چکیده
منابع مشابه
An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation.
Active DNA demethylation (ADDM) in mammals occurs via hydroxylation of 5-methylcytosine (5mC) by TET and/or deamination by AID/APOBEC family enzymes. The resulting 5mC derivatives are removed through the base excision repair (BER) pathway. At present, it is unclear how the cell manages to eliminate closely spaced 5mC residues whilst avoiding generation of toxic BER intermediates and whether alt...
متن کاملColorectal Cancer and Defects in the Mismatch Repair and Base Excision Repair Systems
ABBREVIATIONS ACF aberrant crypt foci APC adenomatous polyposis coli ATM ataxia-telangiectasia mutated BER base excision repair BLM Bloom syndrome gene bp base pair BRCA1 and-2 breast and ovarian cancer genes 1 and 2 CDH1 cadherin 1 CHK2 checkpoint kinase 2 CIMP CpG island methylated phenotype CIN chromosomal instability COX-2 cyclo-oxygenase-2 CRC colorectal cancer CSGE conformation-sensitive ...
متن کاملCoordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers.
DNA damage processing by mismatch repair (MMR) and/or base excision repair (BER) can determine the therapeutic index following treatment of human cancers using radiation therapy and several classes of chemotherapy drugs. Over the last decade, basic and translational cancer research in DNA repair has led to an increased understanding of how these two DNA repair pathways can modify cytotoxicity t...
متن کاملHuman DNA mismatch repair: coupling of mismatch recognition to strand-specific excision
Eukaryotic mismatch-repair (MMR) proteins MutSalpha and MutLalpha couple recognition of base mismatches to strand-specific excision, initiated in vivo at growing 3' ends and 5' Okazaki-fragment ends or, in human nuclear extracts, at nicks in exogenous circular substrates. We addressed five biochemical questions relevant to coupling models. Excision remained fully efficient at DNA:MutSalpha rati...
متن کاملMismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks
DNA interstrand crosslinks (ICLs) are among the most cytotoxic types of DNA damage, thus ICL-inducing agents such as psoralen, are clinically useful chemotherapeutics. Psoralen-modified triplex-forming oligonucleotides (TFOs) have been used to target ICLs to specific genomic sites to increase the selectivity of these agents. However, how TFO-directed psoralen ICLs (Tdp-ICLs) are recognized and ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1997
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.17.2.760